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A systematic review of 194 publications identified 42 cases of EDKA associated with perioperative use of SGLT2 inhibitors [16]

Carnitine shuttle system Carnitine is primarily described as a key player in the degradation of long chain fatty acids (LCFAs) in the mitochondria via the carnitine shuttle system

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[PubMed: 27402097] (Description of an online compendium of cases of liver toxicity attributed to HDS products does not list or discuss alpha lipoic acid)

Factors Requiring Dose Personalization Individual characteristics necessitate dosing adjustments beyond standard protocols for optimal outcomes