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Solid-phase peptide synthesis of D-amino acid chains of this length requires specialized reagents (D-Fmoc amino acids are significantly more expensive than their L-counterparts), extended synthesis times, and careful quality control to ensure correct sequence and sufficient purity

Many patients benefit from beginning treatment at lower doses to minimize adjustment-phase side effects while their body adapts to the medication

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However, it is difficult to determine which is better without comparing the two directly under the same experimental conditions, like in this study