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There are numerous types of therapy available for IC, some of which are extremely complicated, and so as well as carrying out an NMA, a general meta-analysis by effect variables has also been performed

VIP plays a crucial role in immune modulation, reducing inflammation by inhibiting the production of pro-inflammatory cytokines and promoting anti-inflammatory responses (2)

Glutamate participates in diverse physiological processes, such as developmental plasticity and long-term potentiation as well as brain diseases: epilepsy, stroke, amyotrophic lateral sclerosis, Alzheimers disease, Parkinsons disease and schizophrenia (3)

Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis

This "fragment + stabiliser" method is a Russian methodological signature, widely used subsequently by the Khavinson, Myasoedov groups, and more recently by Chinese and Indian teams