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Nkhoma ET, Poole C, Vannappagari V, Hall SA, Beutler E (2009) The global prevalence of glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis

Then, the accumulation of fluid in glands increases the resistance of muscular tissue during the movements of contractions and dilations, and more and more myofibers will be broken and replaced by collagen fibers

These symptoms led to the discontinuation of treatment in 37% of those patients 6

Any signs of unusual bleedingsuch as nosebleeds, bruising, blood in urine or stool, or heavy menstrual bleedingrequire immediate medical attention