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An exploratory DEXA substudy of the STEP 1 trial (140 participants, 68 weeks) found that semaglutide 2.4 mg produced a 19.3% reduction in total fat mass and a 9.7% reduction in total lean body mass with the proportion of lean mass relative to total body mass actually increasing by 3.0 percentage points because fat was lost more rapidly. These results were exploratory and not corrected for statistical multiplicity, so they should be interpreted accordingly