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Options include holding the dose and not escalating further, dropping back to the previous dose, switching to the other medication, adding supportive medications for specific symptoms, or in rare cases, discontinuing treatment entirely

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Conversely, constipation has been shown to persist longer than other GI side effects and is more frequently observed in obesity-focused studies

In the SELECT trial, 17604 adults classified overweight or obesity and established cardiovascular disease, but without diabetes, were randomised to receive semaglutide 2.4 mg weekly or placebo

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