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In the landmark SURMOUNT trials, tirzepatide at the 15mg dose produced average body weight reductions of 20.9% over 72 weeks

Published in 2005, the PROACTIVE trial prospectively enrolled 5,328 patients with T2DM and established CVD to treatment with pioglitazone versus placebo (Figure 4)

This is an impressive result, allowing these drugs to be considered as more than just "weight loss aids." Research into their potential for treating fatty liver disease, alcohol and nicotine addiction, and even Alzheimer's disease is ongoing

In the following section, we will explore the impact of activating GLP-1 signaling on various aging hallmarks, with the aim of potentially extending both lifespan and healthspan, as well as gaining insights into how the modulation of GLP-1R signaling may affect aging at both cellular and systemic levels

The study established the ~6-day half-life, dose-proportional pharmacokinetics, and the 1272 hour Tmax window