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Studies of the biological effect and degradation of glucagon in the rat perifused isolated adipose cell

Intrinsic factor, a protein that shuttles B12 through the absorption process, becomes saturated after a meal containing an above-average amount of B12 and about 4 to 6 hours are required before it can efficiently absorb another dose (IOM, 1998)

First, the effect is enzymatic and cumulative you are shifting a metabolic set-point over days and weeks, not triggering an acute hormonal event, which is why steady daily exposure matters more than any single large dose

A fundamental assumption in neurobiophysics is that all neural activity can be explained through established physical laws (Franze and Guck, 2010)

Its a good idea to ask your doctor about having your B-12 level checked if you are a strict vegetarian or have had weight-loss surgery or have a condition that interferes with the absorption of food