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So far, researchers have understood that side effects, including gastric upset and nausea, tend to occur at the beginning of treatment, but a review of the available literature suggested that the weight loss in the early stages of using the drug, was not linked to nausea

doi: 10.5482/HAMO-14-10-0052 196 PrecupG.TelekyB

And thats an impressive reduction

Volixibat (VLX) is an ileal bile acid transporter (IBAT) inhibitor that interrupts BA uptake in the small intestine, leading to greater BA fecal elimination with subsequent reductions in the systemic BA pool

Glucagon-like peptide-1 (GLP-1) circulates at low levels and acts as an incretin hormone, potentiating glucose-dependent insulin secretion from islet cells