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Furthermore, it has been demonstrated that this hormone can indirectly affect -cells by inhibiting the secretion of other hormones (Strowski et al., 2000

Further studies evaluating the effect of longer-term or central GLP-1R stimulation are still needed to entirely eliminate the requirement of GLP-1 signaling for the food/alcohol suppressing effect of bariatric surgery

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Most findings are derived from in vitro models, underscoring the urgent need for robust in vivo validation in relevant preclinical models