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Mecanismo de ao Estimula a secreo de insulina (glicose-dependente) Inibe a secreo de glucagon Retarda o esvaziamento gstrico Reduz o apetite via ao no hipotlamo Melhora o controle glicmico ps-prandial Pode contribuir com neuroproteo e sade cardiovascular Aplicaes teraputicas Relao com a indstria farmacutica Os medicamentos baseados em GLP-1 se tornaram uma das classes teraputicas de maior crescimento da indstria farmacutica global

13,49,50 Meng et al, in their study on mouse-isolated hepatocytes, reported that a low concentration of metformin (25100 M) activated AMPK, whereas a higher concentration (500 M) inhibited it

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Heartburn or indigestion: Some people notice increased reflux, particularly after larger meals