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Headaches may relate to dose, fluid changes, individual sensitivity, or other health factors

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This creates a vicious cycle : activated mast cells release histamine histamine disrupts sleep poor sleep activates more mast cells more histamine release

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Misfolded wild type SOD1 is observed in sALS cases and the existing treatments for SOD1-related fALS, such as the antisense oligonucleotide therapy Tofersen, may have a possibility to be applied to these sALS cases (Marlow et al., 2025)