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A review of randomized trials found that L-tyrosine, a precursor to dopamine and norepinephrine, helped maintain attention and reaction time under acute stressors such as cold or sleep loss, with no clear benefit at rest

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NAD precursors cycle between host tissues and the gut microbiome

Notably, the ER lacks glutathione reductase activity 12 and instead appears to rely on the transport of excess GSSG to maintain its optimal redox environment 10