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[3] Prolonged therapy can unmask or exacerbate benign prostatic hyperplasia, raise prostate-specific antigen, worsen untreated obstructive sleep apnoea and is associated in some observational studies with a small but controversial increase in cardiovascular events, underlining the necessity for baseline and periodic monitoring of PSA, lipids and cardiovascular risk factors

These additional codes paint a complete picture of the patients condition and help healthcare teams provide appropriate care

Their effects are mediated via NK1 receptors (mainly for SubP) and NK2 receptors (activated by NKA)

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However, most of this research has been conducted in animal models, and human safety and efficacy data are limited