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In R161H mice, broad-spectrum antibiotic treatment reduced intestinal Th17 cell activation and alleviated uveitis, while in vitro studies demonstrated that bacteria-rich intestinal extracts directly activated IRBP-specific T cells, highlighting the role of gut microbial antigens in driving autoreactive T cells (102)

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The molecule can be described as a modified dipeptide analogue featuring multiple stereocenters and flexible aliphatic segments

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Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-alpha-lipoic acid