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Interestingly, silencing of oct 3 transporter in mice attenuates both the MPP + release from astrocytes and the subsequent impairment of dopaminergic neurons, in which makes oct3 as an important molecular target for dopaminergic related pathologies [6,84]

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GLP-1 medications, such as semaglutide (Wegovy, Ozempic) and tirzepatide (Mounjaro, Zepbound), were originally developed for type 2 diabetes and later approved for chronic weight management at full therapeutic doses

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