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While -3 PUFAs are considered to have beneficial effects 40 , consumption of PUFAs has also been linked with more severe ALD in humans and experimental animals 41

All assessments were conducted by an experienced technician under blinded conditions

Melatonin is responsible for increasing the expression of the mediator that interacts with Bcl-2 (Bim), activating the transcription of the FoxO3a factor, and increasing its concentration in the nucleus [30]