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Gopal Grandhige, MD, FACS, Board-Certified Surgeon Last Reviewed: February 15, 2026 Ipamorelin is a synthetic pentapeptide that stimulates your bodys natural growth hormone production by activating growth hormone secretagogue receptors in the hypothalamus and pituitary gland

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H&E staining results further confirmed that the aortic wall thickness of mice treated with FOXO4-DRI was significantly thinner, and ultrasound examination results showed that the PWV of the aorta was slowed down after FOXO4-DRI treatment, indicating better vascular elasticity and significantly improved vascular function compared to the control group (Figures 2D,E)