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Gut ischemia can elevate ammonia

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In the body, bilirubin is excreted as waste, but bilirubin can serve as an antioxidant molecule, and the bilirubin-biliverdin redox couple has direct antioxidant function [80]

These preliminary findings suggest that mesotherapy with a synergistic combination of antioxidant and depigmenting agents may offer a viable, conservative alternative to conventional depigmentation techniques