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1998 pharmacology paper showed that ipamorelin did not raise ACTH or cortisol to levels significantly different from GHRH stimulation alone, and this finding held even at doses more than 200-fold above the ED50 for GH release

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The cavities were calculated using a modified LIGSITE algorithm (Hendlich et al., 1997)

I get a lot of pushback on that from physicians saying, Why would you want to burden a patient with that knowledge? I welcome that debate because it opens a discussion: Do you or do you not believe that this a deterministic gene