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Additional evidence for an independent intrarenal RAS included observations that intrarenal ANG II contents markedly increased compared to circulating levels

Eligible patients in Maryland and Delaware may receive in-person or telehealth care based on their location and clinical needs Some patients notice changes in appetite during the first few doses, while others require gradual dose escalation before experiencing a meaningful effect

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Direct head-to-head comparisons are not possible because the trials differed in duration, population and study design, but reporting outcomes side-by-side provides context