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albicans exhibits remarkable intraspecific strain heterogeneity, which is driven by genetic variations including aneuploidy, loss of heterozygosity, copy number variations and single nucleotide polymorphisms, as well as epigenetic phenotypic switching and niche-specific adaptive regulation, and this heterogeneity directly leads to significant differences in pathogenicity, biofilm formation ability and drug responsiveness among different strains (Hirakawa et al., 2015)

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Velasquez-Mieyer PA, Cowan GSM, Buffington CK, Arheart KL, Connelly BE, Spencer KA, Lustig RH: Primary insulin hypersecretion: a specific and remediable subtype of obesity

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