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Natural products appear to exert modulatory effects on this system, either by activating protective autophagy to clear damaged organelles and reduce oxidative load, or by inhibiting excessive autophagy to prevent unnecessary cellular degradation

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The most cited mechanistic finding is the Neelakantan and colleagues 2018 study in Biochemical Pharmacology , in which the investigators reported that 5-Amino-1MQ reverse[s] high fat diet-induced obesity in mice through selective inhibition of the NNMT enzyme, with measurable reductions in adipose tissue mass, improvements in insulin sensitivity, and increases in adipose tissue cellular metabolic activity in C57BL/6 mice fed a 60% kcal-from-fat diet [1]

Front Microbiol 8 , 831 (2017)