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Although cytokines are mainly produced by the immune system, there is also an unclear link between neuroinflammation and these peripheral proinflammatory cytokines (201)

It plays a role in neutralizing oxidative stress and may even contribute to cardiovascular health in moderate amounts

Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid

Systemic GLP-1R agonist pharmacotherapy reduces activity of VTA dopamine neurons and attenuates cocaine seeking Systemic GLP-1R agonist administration reduced cocaine-evoked dopamine release in the nucleus accumbens 32 , a downstream target of VTA dopamine neurons known to play a critical role in cocaine seeking 33,34

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