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This might explain the results of Nagler who demonstrated a significant decrease in NO in the saliva of heavy smokers

111 The only acceptable alternative endpoint in drug development, histological evidence, consists of the resolution of steatohepatitis and no worsening of liver fibrosis, or improvement in liver fibrosis of at least one stage without worsening of steatohepatitis

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As with any treatment that influences your body's systems, there are potential risks, such as hormonal shifts or other side effects

There was no significant publication bias (p=0.5) (Fig