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Besides exercise and nutrition, the paper also highlights weight loss, caloric restriction, and metabolic flexibility as key strategies to reduce oxidative load and improve glutathione recycling

doi: 10.1038/s41467-020-17183-8 194 VavassoriP.MencarelliA.RengaB.DistruttiE.FiorucciS

However, the precise regulatory mechanisms of cell death in this process require further investigation (212)

291 We propose a call to action for accelerated translation of mitochondrial-targeted therapies for HF, both alone or in combination with current therapeutic options, including SGLT2i