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Further, therapeutic drugs with high liposolubility have longer retention and duration of action in non-target peripheral organs, causing considerable side effects

Abstract We report the design and target validation of chimeric peptide EP45, a novel 45 amino acid monomeric dual agonist peptide that contains amino acid sequence motifs present within the blood glucose-lowering agent exendin-4 (Ex-4) and the appetite-suppressing agent PYY(336)

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Other Orange / reddish-brown urine discoloration (harmless) Fatigue Increased sweating Rare but serious: Severe diarrhea dehydration Hepatotoxicity (rare compared to Tolcapone) --- 8

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