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Dysfunctional hypothalamic function can be seen in ME/CFS patients in the form of up-regulation of hypothalamic 5-hydroxytryptamine (5-HT) receptors (441) and abnormal arginine/vasopressin responses to deprivation tests and water loading (440)

Clinical trial data provides averages, but every patient responds differently

The FDA maintains the boxed warning because proving a negative, proving that something definitively does NOT cause cancer, requires decades of surveillance data