Eduardo Grunvald, M.D., FACP, Medical Director of the University of California San Diego Center for Advanced Weight Management, though he points out that the benefits of treating obesity outweigh that risk
First-generation GLP-1 receptor agonists necessitated once or twice-daily dosing, resulting in substantial peak-to-trough variations that caused inconsistent glycaemic regulation and heightened gastrointestinal adverse effects (Nauck and Meier 2019)
Pasternak B, Wintzell V, Hviid A, Eliasson B, Gudbjrnsdottir S, Jonasson C, et al
This can be especially appealing for patients who are nervous about nausea, have a history of medication sensitivity, are close to their goal weight, want help with food noise rather than aggressive weight loss, or prefer a more conservative plan
The mechanisms behind GLP-1 induced gastroparesis and mechanical obstruction are quite different