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Polyphenols activate the redox-sensitive transcription factor nuclear factor erythroid 2-related factor-2 (Nrf2) (166)

It was observed that niacinamide significantly reduces total sebaceous lipogenesis in a dose-dependent manner, an effect likely attributable to a reduction in triglycerides, which make up the predominant proportion of sebaceous gland lipids (up to 57.5%)

Van Dam, R

Since these drugs have surged in popularity (even triggering availability shortages), both the media and users have reported on a few of their downsides

Beyond the known triggers like pregnancy and birth control pills, here are a few donts of melasma: Use tanning beds or tan naturally Exfoliate everyday Wax or shave in afflicted areas Seek out LED treatments Go into the sun without protective clothing and/or sunscreen Is Melasma Preventable