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Constipation Advise patients of the potential for severe constipation, including management instructions and when to seek medical attention [seeADVERSE REACTIONS,CLINICAL PHARMACOLOGY]

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Together, the epithelial cells, intercellular proteins, and mucins form a layer that plays important physical and functional roles in separating the luminal microbiome from the immune cells that inhabit the lamina propria [16]

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