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Dual-pathway synergy: Veldhuis and colleagues demonstrated in human physiological studies that simultaneous activation of GHRH receptor and GHS receptor pathways produces GH pulse amplitudes exceeding additive predictions

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Critically, AOD-9604 did not produce the metabolic side effects associated with full-length growth hormone, including no insulin resistance or glucose intolerance, no elevation of IGF-1 levels, no fluid retention or joint pain, and no cardiovascular parameter changes

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