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GLP-1 receptor agonists, originally developed for type 2 diabetes management, had become blockbuster weight loss drugs

New-onset or worsening fatigue in established users warrants investigation for alternative causes, including thyroid dysfunction, anemia, vitamin deficiencies, or other medical conditions that may have developed independently of the medication

The medication works by activating both GIP and GLP-1 receptors, enhancing insulin secretion in a glucose-dependent manner, suppressing glucagon release, slowing gastric emptying, and reducing appetite

doi: 10.2478/v10153-010-0040-z 163 CostaRTamasciaMLSanchesAMoreiraRPCunhaTSNogueiraMDet al

Thus supplementation is often required to maintain healthy levels.