Their mechanisms enhance insulin sensitivity, reduce hepatic fat synthesis, improve lipid metabolism, and alleviate steatosis (Yabut and Drucker, 2023)
The semaglutide group showed a significantly improved Kansas City Cardiomyopathy Questionnaire clinical summary score and a longer 6-min walking distance from baseline (21.5 m and 1.2 m in the semaglutide and placebo groups, respectively, intergroup difference 20.3 m, 95% CI 8.632.1 m), compared with that in the placebo group despite the relatively short observation period of 52 weeks
Not yet and not without physician involvement regardless of regulatory timing
The side effects, particularly gastrointestinal, can impact quality of life for some users a few may find the nausea or digestive upset intolerable and discontinue the drug
They interfere with eating, speaking, and overall confidence