fda glp-1 safety alert october 2025 How safe are GLP-1s? September 8, 2025: FDA launches

Tier 3 conditions in detail: Prediabetes The American Diabetes Association defines prediabetes as fasting plasma glucose of 100 to 125 mg/dL, a 2-hour plasma glucose of 140 to 199 mg/dL on an oral glucose tolerance test, or an A1c of 5.7 to 6.4 percent

GLP-1 medications can lead to up to 3040% of weight lost coming from lean muscle mass, whereas ESG tends to result in only about 1015% muscle loss, making it more effective at preserving lean body mass during weight reduction due to its mechanical rather than hormonal weight loss mechanism

Some private prescribers offer it off-label for weight management, but the NHS wont prescribe it for that purpose

De Giorgi R, Koychev I, Adler AI, Cowen PJ, Harmer CJ, Harrison PJ, et al

Seek immediate care for signs of serious allergic reactions including widespread rash, facial swelling, or difficulty breathing