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Additionally, we have summarized the different PTMs and epigenetic modifications of NRF2 and their impacts on diseases (Fig

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doi: 10.1074/jbc.M001706200

As shown in Table 1, these adverse reactions include gastrointestinal discomfort and the risk of lactic acidosis (for biguanide drugs), severe hypoglycemia (for sulfonylurea drugs), and possible exacerbation of insulin resistance (for insulin)