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The underlying cause of deficiency is the most important determinant

Stimulants cause tolerance development, meaning increasing doses are needed for the same effect

[44] In the cytosol [edit] Methylcobalamin and 5-methyltetrahydrofolate are needed by methionine synthase in the methionine cycle to transfer a methyl group from 5-methyltetrahydrofolate to homocysteine, thereby generating tetrahydrofolate (THF) and methionine, which is used to make SAMe

The bottom line While vaccines are generally safe with small to moderate amounts of alcohol, its best to wait a day or two until the side effects dissipate

Usually resolves within hours