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Intrinsic factor is efficient at absorbing a high percentage of a small dose of B12, but it becomes saturated after a meal containing an above-average amount of B12, and about 4 to 6 hours are required before it can efficiently absorb another dose (Institute of Medicine, 1998)

Metformin , the first-line treatment for type 2 diabetes, is associated with reduced B12 levels in approximately 1030% of long-term users

For a broader look at why methylated vitamins matter across your entire prenatal stacknot just B12we've broken it all down

You may have a deficiency if you are vegan, if you have other health conditions which mean you are unable to absorb it properly such as pernicious anaemia, you take disruptive medications such as antacids or other lifestyle factors such as alcohol intake

[1] [2] In those with mild symptoms, weight loss, decreasing caffeine intake, and exercise are recommended, although the quality of the evidence for exercise is low