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No single or dual-agonist compound can replicate the combined effects on appetite regulation, insulin secretion, lipolysis, and thermogenesis that retatrutide produces in research settings

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In subjects with ESRD, the ratio of the observed AUC of semaglutide from 144 to 148 h during haemodialysis (day 16) over the predicted AUC of semaglutide from 144 to 148 h (AUC 144148 h,dial /AUC 144148 h,pred ) was calculated using the terminal elimination rate ( z ) (as estimated using the semaglutide plasma concentrations between two haemodialysis sessions at 76, 96, 120 and 144 h) after the tenth dosing