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This phase three, randomized, double-blind, placebo-controlled clinical trial was completed in July 2024 and included 731 participants aged forty and older

Their rates of depressive symptoms were markedly higher than the 15 to 22% in an ethnically diverse sample of primary care patients and the 5.6% among overweight and obese US adults

In the large SUSTAIN and PIONEER trials, only about 2060% of the CRP reduction was explained by weight and glycaemia

Clinical experience shows that patients who drink at least 3 liters of water daily and consume electrolyte-balanced foods or supplements report significantly fewer muscle cramps

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