A recent propensity-matched cohort study also identified obesity as a risk factor for corticosteroid use, therapy escalation, and colectomy in UC patients (85)
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Like GLP-1, GIP is released after ingestion of nutrients, and promotes meal-stimulated insulin secretion in a glucose-dependent manner by receptor binding to pancreatic -cells
observed no statistically significant differences in disease exacerbation, corticosteroid-free remission, or therapy escalation in the same cohort of 224 IBD patients after one year of GLP-1 RAs treatment
Pharmacists When counselling patients who are starting a GLP-1 receptor agonist, inform them of the potential for delayed gastric emptying and the associated risk if they are to undergo any procedures or imaging that involves anesthesia (for which a fasting period or empty stomach is required)