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doi: 10.2165/00044011-200222001-00002

Taking doses too close together can sometimes increase the risk of side effects

Overall Evidence for the Use of B12 for Painful Peripheral Polyneuropathy Taking into account the above evidence, there is level III evidence overall to support the use of B12 either as monotherapy or as a combination therapy for treating neuropathic pain caused by peripheral polyneuropathy

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Guerin P, El Mouatassim S, Menezo Y