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NICE TA664: Liraglutide for managing overweight and obesity supporting document 129

These drugs are particularly valuable for patients with obesity-related conditions like metabolic syndrome, prediabetes, or as recently approved, obstructive sleep apnea (OSA) the FDA approved tirzepatide in OSA because weight loss led to significant improvement in apnea-hypopnea index and symptom resolutionfda.govfda.gov

Seek urgent medical advice if you experience: Severe, persistent vomiting that prevents you from keeping down food, fluids, or other medications Signs of dehydration , including dark urine, dizziness, extreme thirst, or reduced urination Severe abdominal pain , particularly if constant or accompanied by fever Vomiting blood or material that looks like coffee grounds Black, tarry stools or blood in your stools Unexplained, rapid weight loss Difficulty swallowing or pain when swallowing Symptoms of pancreatitis : severe upper abdominal pain radiating to the back, often with nausea and vomiting If you suspect pancreatitis, stop taking Victoza immediately and seek urgent medical attention

This expansion or duplication of genes resulted in sequence variations that expanded substrate functionality and/or responses to environmental stresses [62, 70, 71]