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In research it is valued as one of the most selective growth hormone secretagogues: it prompts GH release while having little effect on other hormones such as cortisol or prolactin, giving researchers a clean tool for studying this pathway

It has been suggested that the higher risk observed with tirzepatide relative to semaglutide may be attributed to the use of higher doses of tirzepatide

A study conducted in March 2025 involving 350,000 patients found that two years of Ozempic use more than doubled the risk of developing the condition compared to alternative diabetes treatments

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Biol Trace Elem Res 143(2):603611 Maxel T, Smidt K, Larsen A, Bennetzen M, Cullberg K, Fjeldborg K, Lund S, Pedersen SB, Rungby J (2015) Gene expression of the zinc transporter ZIP14 (SLC39a14) is affected by weight loss and metabolic status and associates with PPAR in human adipose tissue and 3T3-L1 pre-adipocytes