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Therapeutics 33 (3), 358371.e2

Furthermore, the activation of EPAC2 stimulates the release of calcium from the endoplasmic reticulum, which raises intracellular calcium levels and promotes exocytosis

In addition, they have shown linagliptin has protective effects on human islets against cytokines-induced toxicity as well as gluco- and lipotoxicity that are often associated with diabetes development 28

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Due to the low bioavailability of SL, its concentration in humans rarely reaches a level that constitutes significant inhibition ( Previous studies have shown that SL protected against various types of drug-induced liver injury