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It binds to the antioxidant glutathione, enhancing the production of ROS, and leading to inflammation and mitochondrial damage [42, 43]

To improve the reliability of signals and avoid occurring false positive signals, a signal was regarded as positive only when it met all criteria of four algorithms simultaneously ( Results Descriptive analysis From January 2018 to June 2022, a total of 231,730 GLP-1 RA-associated AEs reports were recorded, of which 21,281 reports of gastrointestinal AEs were identified

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