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Additionally, preclinical animal models provide mechanistic insights but may not fully translate to human physiology, particularly in conditions such as osteoporosis, obesity-related bone changes, and joint infections

Peptides can support metabolic pathways related to insulin sensitivity, inflammation, and hormone balance

Better tolerability (lower total dose needed)

Important cautions shared across this drug class: Thyroid C-cell tumours in rodents: long-acting incretin drugs carry a rodent finding that leads to caution in people with a personal/family history of medullary thyroid carcinoma (MTC) or MEN2

Additionally, semaglutide acts on appetite-regulating centers in the hypothalamus, promoting satiety and reducing caloric intake, which contributes to weight loss