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In this work, we observed that transcripts encoding GpoA are significantly upregulated following exposure to H2O 2 , aligning with its specialized role in H 2 O 2 detoxification

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Allosteric modulation Comparing the structures of GLP-1(9-36)GLP-1R with and without LSN3318839 reveals significant spatial overlaps between the first N-terminal helical turn of GLP-1(9-36) (residues T11 P S14 P ) and LSN3318839, with F12 P being the most prominent overlay ( Fig