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The angiogenesis and disruption of liver vascular architecture have been linked to progression to cirrhosis and liver cancer in chronic liver diseases, which contributes to both increased hepatic vascular resistance and portal hypertension and decreased hepatocyte perfusion [119,120,121]

The confirmatory secondary endpoints included the change in the 6-min walking distance, a hierarchical composite of death and heart failure events

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Effects on cellular NAD+ and SAM pools in vitro