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Corticosterone measurements Plasma corticosterone levels were measured using radioimmunoassay (MP Biomedicals, Santa Ana, CA)

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Discontinuation rates due to adverse events were reported as low and single-digit across both REDEFINE 1 and 2, which Novo Nordisk highlighted as a positive tolerability signal given the drugs dual-mechanism approach

A 2023 study showed that those who consumed 0.66g of protein per Kg per day had low levels of Glutathione vs those who consumed 1.0g of protein per Kg per day